Estradiol
Main Entry: esˇtraˇdiˇol
Pronunciation: es-tr - d - l, - l
Variant(s): or chiefly British oesˇtraˇdiˇol / -str - d - l, - strad- - l, - l/
Function: noun
: a natural estrogenic hormone that is a phenolic alcohol C18H24O2 secreted chiefly by the ovaries, is the most potent of the naturally occurring estrogens, and is administered in its natural or semi synthetic esterified form especially to treat menopausal symptoms -- called also dihydrotheelin
Estradiol, a type of estrogen, protects against brain injury, including injury from stroke, neurodegeneration and cognitive decline. There are two estrogen receptor types, ERa and ERb. Using animal models in which one of the receptor types had been deleted, they demonstrated that when ERa is absent, estradiol no longer has protective effects in any area of the brain. But when ERb is absent, estradiol still provides effective neuro-protection. This shows that they should mainly focus on Era because they have major effects on treating brain injuries.
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