Motilin

Main Entry: mo·til·in
Pronunciation: m - til- n
Function: noun

: a polypeptide hormone secreted by the small intestine that increases gastrointestinal motility and stimulates the production of pepsin

Motilin is a 22 amino acid peptide secreted by endocrinocytes in the mucosa of the proximal small intestine. Based on amino acid sequence, motilin is unrelated to other hormones. Motilin participates in controlling the pattern of smooth muscle contractions in the upper gastrointestinal tract. There are two basic states of motility of the stomach and small intestine : the fed state, when foodstuffs are present, and the inter-digestive state between meals. Motilin is secreted into the circulation during the fasted state at intervals of roughly 100 minutes. These bursts of motilin secretion are temporally related to the onset of "housekeeping contractions", which sweep the stomach and small intestine clear of undigested material (also called the migrating motor complex ).

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