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GlucocorticoidMain Entry: glu·co·cor·ti·coidPronunciation: - k rt-i- k id Function: noun : Any of a group of corticosteroids (as cortisol or dexamethasone) that are involved especially in carbohydrate, protein, and fat metabolism, that tend to increase liver glycogen and blood sugar by increasing gluconeogenesis, that are anti-inflammatory and immunosuppressive, and that are used widely in medicine (as in the alleviation of the symptoms of rheumatoid arthritis). Glucocorticoids are a class of steroid hormones characterized by an ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by the specific receptors, target cells, and effects. Technically, corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Cortisol (or hydrocortisone) is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic , immunologic , and homeostatic functions. Glucocorticoid receptors > are found in the cells of almost all vertebrate tissues.
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