|
.
Deoxypyridinoline is present in urine during bone degradation. Deoxypyridinoline, or Dpd, is tested in the urine to determine the presence of osteoporosis, or other bone related diseases. Your bones are always undergoing a metabolic process that is medically referred to as remodeling. This includes a degradation process, bone resorption mediated by the action of osteoclasts, and a building process, bone formation, mediated by the action of osteoblasts. Remodeling of bones is necessary for the maintenance and complete bone health for resorption and formation to be in balance. In some abnormal states of bone metabolism, and some normal physiological states, like menopause, this process becomes uncoupled, and when resorption out weighs formation, there is a net loss of bone. The measurement of exact degradation products of bone matrix provides the rate of bone metabolism by analytical data.
There are certain tests that can be used to evaluate bone resorption rates in healthy individuals and also in those who have a higher risk of developing metabolic bone disease. Considerably high levels of deoxypyridinoline, or Dpd, are found in post-menopausal women caused by an estrogen deficiency. Deoxypyridinoline tests can also determine high levels of Dpd in individuals with diseases that have high bone turnover rates. Deoxypyridinoline can be used to monitor anti-resorptive therapies (which may include bisphosphonates) in postmenopausal women and in those diagnosed with osteoporosis.
Deoxypyridinoline is a marker of bone turnover and tests are usually measured by the urine from patients with osteoporosis. Methods of urine collection vary: usually urine samples are taken from 24 hour urine, 2nd morning sample, and an 8 hour sample. It is usually shown as a ratio with urinary creatinine concentration.
Source: Dec. 1, 2005. http://www.northbaydiagnostics.com/PYRILINKS.html.
___________________
text provided by megan
Copyright 2005, | buy tramadol Bioidentical Medical Dictionary | Bioidentical Pages
|
Bio Identical Medical Definitions
|
|
