Androgens

Main Entry: an·dro·gen

Pronunciation: an-dr -j n
Function: noun
: a male sex hormone (as testosterone)
- an·dro·gen·ic / an-dr - jen-ik/ adjective

For many years, castration has been the only known strategy cure for metastatic prostate cancer. Prostatic tumors need androgenic hormones to grow, and until now, efforts to chemically block all of these hormones have proven disappointing. However, researchers at the University of Maryland School of Medicine have identified new androgen inhibitors that they believe could supplant castration as the primary method of treatment for prostate cancer.

Dr. Angela Brodie, professor of pharmacology and experimental therapeutics, and research fellow Yang-zhi Ling, believe that several inhibiting compounds discovered in their research may now be the first and most promising treatments of prostate cancer.

"It's been known for some time that total androgen inhibition could be more effective than castration, but we hadn't been able to identify and synthesize a compound that would suppress both testicular and adrenal androgens," said Brodie. "Despite removal of the testes, some prostatic tumors can be stimulated even by very low levels of androgens, and some adapt well enough to convert adrenal androgen into a stronger androgen called DHT. These compounds show promise of a more thorough blockade, even against these more difficult tumors, than any we've seen before."

 

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Copyright 2005-2006 Bioidentical Medical Dictionary

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